An Airbus A320 airliner has crashed in the French Alps between Barcelonnette and Digne, French aviation officials and police have said.
The jet belongs to the German airline Germanwings, a subsidiary of Lufthansa.
The plane had reportedly been en route from Barcelona to Dusseldorf and was carrying 142 passengers and six crew.
French President Francois Hollande said: “The conditions of the accident, which have not yet been clarified, lead us to think there are no survivors.”
Hollande said the crash was a tragedy and called for solidarity with the victims, adding that the area of the crash was very difficult to access, reports the BBC.
The plane had issued a distress call at 10:47 (09:47 GMT), according to sources quoted by AFP news agency.
French Prime Minister Manuel Valls said he had sent Interior Minister Bernard Cazeneuve to the scene and a ministerial crisis cell to co-ordinate the incident had been set up.
Both Airbus and Germanwings have said they are aware of the reports but cannot yet confirm them.